As expected, silencing lncRNA-H19, -MALAT1, and -PVT1, positively correlated with liver fibrosis, resulted in a significant decrease in α-SMA expression in JS-1 cells by approximately 46.59%, 41.02%, and 64.30% (P < 0.001), respectively. The gene discussed is PVT1; the disease is Hepatic fibrosis.