Silencing of lncRNA-H19, -MALAT1, and -PVT1 resulted in a significant decrease in the expression of α-SMA and collagen I. Conversely, silencing of lncRNA-P21 and -GAS5 led to a significant increase in the expression of α-SMA and collagen I. These findings suggest a positive correlation between lncRNA-H19, -MALAT1, and -PVT1 with liver fibrosis, while lncRNA-P21 and -GAS5 exhibit the opposite trend. The gene discussed is PVT1; the disease is Hepatic fibrosis.