The genes of SOCS5 (a gene encoding for an inhibitor of cytokines), CD207 (an atypical antigenic pathway gene involved in promoting the uptake of antigens for T cell expression), and ITGB3 (a gene encoding an integrin protein engaged in cell adhesion and surface signal regulation), are involved in the occurrence of EN and the inflammation of IBD [18]. The gene discussed is ITGB3; the disease is inflammatory bowel disease.