In a large microarray panel screening for differentially expressed genes in peripheral blood, inflammation related genes were found to be upregulated in CH patients as compared to controls (major histocompatibility complex, class II (HLA) -DQA1 and HLA-DQB1), or specifically during active bouts (S100 calcium binding protein (S100) A8 and S100A12) [6]. Here, S100A12 is linked to cyclic hematopoiesis.