Analysis of CSF cytokine levels in controls and CH patients showed differences in nine cytokines; CCL8, CCL13, CCL11, CXCL10, CXCL11, hepatocyte growth factor (HGF), matrix metallopeptidase (MMP) 1, TNF superfamily member (TNFSF) 10 and TNFSF12 (Fig. 1, Supplementary Table 1). The gene discussed is TNFSF12; the disease is cyclic hematopoiesis.