Furthermore, the most crucial signaling pathway associated with Alcoholic Liver Disease (ALD) is presented in Supplementary Fig. 1, featuring target genes such as IL6, IL1B, TNF, TLR4 receptor, and alcohol dehydrogenases (ADH1A, ADH1B, ADH1C, and ADH5). The gene discussed is AKR1A1; the disease is alcoholic liver diseases.