Multivariate analysis demonstrated that LN (odds ratio [OR] (95% confidence interval [CI]) 3.68 (1.14, 11.83), P = 0.029), C3 (OR (95% CI) 0.10 (0.01, 0.99), P = 0.049), IgG (OR (95% CI) 1.18 (1.03, 1.35), P = 0.015), serum ALB (OR (95% CI) 0.86 (0.79, 0.99), P = 0.029), CRP (OR (95% CI) 1.02 (1.01, 1.04), P = 0.012) and HCQ (OR (95% CI) 0.28 (0.09, 0.92), P = 0.036) were independent risk factors. The gene discussed is C3; the disease is lobular neoplasia.