After adjustment for significant factors identified in the baseline characteristics including ALT, AST, triglycerides, Non-HDL cholesterol, uric acid, BUN, and poverty income ratio, high SII level was an independent risk factor for NAFLD (OR = 3.505, 95% CI: 1.092–11.249, P < 0.05, Table 3). The gene discussed is GPT; the disease is metabolic dysfunction-associated steatotic liver disease.