In this study, among HBeAg-positive patients with normal ALT, HBV DNA levels are negatively correlated with liver fibrosis (r=-0.217, p = 0.004), (Supplementary Figs. 3 and 4), which is in conformity with the results of a previous study of HBeAg-positive patients(r=-0.491, p < 0.001) [25]. This evidence concerns the gene GPT and Hepatic fibrosis.