Some recent studies have found that a sizable number of HBeAg-positive CHB patients with persistently normal ALT have significant liver injury [9], suggesting a high risk of liver cirrhosis and HCC, and some studies have demonstrated that HBV-specific T cells, HBV DNA integration and clonal hepatocyte proliferation were the immune tolerance patients’ specific charateristics [10–12]. Here, GPT is linked to cirrhosis of liver.