These results were confirmed in SUM159PT cells (SUMWT), a breast cancer cell line, where Cx43 KO (SUMCx43KO) led to a significant increase in the intensity of Gal3 puncta over the washout time, suggesting a reduced recovery ability to endomembrane injury when compared to parental cells expressing endogenous levels of Cx43 (Appendix Fig. S2d,e). This evidence concerns the gene LGALS3 and breast cancer.