SLC27A1 and Alzheimer disease: Since FATP1 is known to be preferentially expressed in the abluminal membrane of brain endothelial cells [18] and iron overload is observed in AD [23, 24], these findings provide an insight on how iron overload can be a contributing factor to the reduction in brain DHA levels observed in AD stemming from reduced the efflux of DHA from the brain endothelial cells into the brain.