CD8A and cancer: In addition, ccRCC is notable for its highly immune-infiltrated tumor microenvironment (TME) [15], which includes the enriched immune cells [i.e. B cells, defected CD8+ T cells [16], myeloid-derived suppressor cells (MDSCs), tumor associated macrophages (TAMs) [17]] and non-immune cells [i.e., cancer-associated fibroblasts (CAFs)] [18], as well as extracellular elements [19], showing an overall pro-inflammatory and angiogenesis profile [20].