The relationship between oxidative stress and the activity of AQP4 was also observed in a brain ischemia model, where the treatment with antioxidants such as resveratrol and Edaravone markedly reduced AQP4 protein levels, limiting edema formation and lesion area (Alquisiras et al. 2020; Li et al. 2015). The gene discussed is AQP4; the disease is brain ischemia.