RAC1 and infection: Immunoprecipitation (IP) assays showed that infection by the EF, EF::RDTND-RIDC/A, EF::RDTNDE/Q-RIDC/A, or EF::RDTND4mt-RIDC/A led to a marked increase in the NOX2/gp91phox interaction with Rac1, p47phox, and p67phox in macrophages (Fig. 5f).