Multiple glutamate (e.g. Grin2c, Gria2) and GABA (e.g. Gabrb1, Gabrg1) receptors, glutamate (e.g. Slc1a2) and GABA (e.g. Slc6a11) reuptake transporters and other solute carrier (SLC) transporters, involved in amino acid import (e.g. Slc7a10) were robustly downregulated in all reactive astrocyte subclusters, within both infarction severities (Fig. 4j, Supplementary Fig. 21i). This evidence concerns the gene GRIA2 and infarction.