SPP1 and infarction: Likewise, significantly more Iba1+/OPN+ cells were identified in the affected WM (226.3 ± 135.3/mm2) as compared to the WM contralateral to infarction (11.385 ± 18.25/mm2) and the comparison to Sham WM (11.6 ± 9.5/mm2) approached statistical significance (Fig. 6d).