Using the modified HLA-DR4α-eno-15cit10-22V20G tetramer we successfully isolated and obtained paired TCRαβ sequence of a further 11 CD4+ T cells from the peripheral blood of ACPA+ RA donor 2 as well as two CD4+ T cells from another RA donor 3 and 20 and 15 CD4+ T cells, respectively, from two HLA-DR4+ healthy donors (Supplementary Table 1). Here, CD4 is linked to rheumatoid arthritis.