We expressed and purified five TRAV6+ TCRs from the immune mouse T cell repertoire (HLA-DR4Vim-64cit59-71 restricted TCRs A03 and A07 and HLA-DR4α-eno-15cit10-22 restricted TCRs E02, E04, and E17), (Fig. 1c), and the two TRAV26-1+ TCRs isolated from human RA+ PBMCs (HLA-DR4Vim-64cit59-71 restricted TCR RA2-A03 and HLA-DR4α-eno-15cit10-22 restricted TCR RA2.7) (Fig. 2c). This evidence concerns the gene TRAV6 and rheumatoid arthritis.