Intriguingly, the CDR1α residues (asparagine and tyrosine) either at positions 36 and 38 of TRAV6+ TCRs, or vice versa in TRAV26-1+ TCR, made similar contacts with P2 of peptide and HLA-DR4 β-chain, thus underscoring the relevance of the mouse transgenic model to that of human RA. This evidence concerns the gene TRAV26-1 and rheumatoid arthritis.