However, in T- and B-cell-null Rag1-deficient (Rag1-/-) mice, colon cancer growth was mildly inhibited following Tri-NAb treatment (Supplementary Fig. 33), but this effect was not as pronounced as that observed in immunocompetent C57BL/6 mice (Fig. 4f). Here, RAG1 is linked to malignant colon neoplasm.