TTR and heart failure: The incidence rate of heart failure was 1.92 (95% Confidence Interval = 1.74–2.12) per 1,000 person-years and 2.39 (95% Confidence Interval = 2.19–2.62) per 1000 person-years in individuals with high and low TTR levels, respectively. (Table 3) The risk of heart failure increased by 17% per SD decrease in TTR levels [HRadj: 1.17 (95% Confidence Interval = 1.08–1.26)].