Here, our data confirm that PRMT6 mediates the asymmetric dimethylation of histone H3 at arginine 2 (H3R2me2a) to inhibit the transcription of TRAF6, resulting in a significant decrease in the expression levels of TRAF6 in glioblastoma cells with PRMT6 overexpressing. This evidence concerns the gene TRAF6 and glioblastoma.