Further investigation into the 100 bp∼−2000 bp region encompassing the TRAF6 promoter in glioblastoma cells demonstrated that PRMT6 and H3R2me2a were significantly enriched at 1400 bp∼1101 bp (F5) and 2000 bp∼1701 bp (F7) upstream of the TRAF6 transcription start site (Figs. 5H and S3A, B). The gene discussed is TRAF6; the disease is glioblastoma.