Furthermore, the proportion of T-cells transduced with FGFR4.28HTM.28z-CD276.8HTM.BBz BiCisCAR that expressed exhaustion markers was significantly lower within tumor (CD39 and Tim-3) and in the blood (CD39 and LAG-3) compared to those observed with other CARs (Fig. 4L–O; Supplementary Fig. 8B–E). The gene discussed is ENTPD1; the disease is neoplasm.