Brain resilience is essential in neurodegenerative diseases because the brain needs to cope with neuropathologic accumulation while retaining its functional properties and performance.10 While brain resilience to tau neuropathologic burden was shown to be altered and linked to age and sex in Alzheimer disease (AD),11 studies on structural brain network resilience in PD have not been performed yet. The gene discussed is MAPT; the disease is Parkinson disease.