This cytokine is associatedwith GBM cell invasion and proliferation by regulating and activatingp65 (subunit of the NF-κB transcription factor complex) andprotein kinase B (PKB, also known as Akt) signaling pathways.58,59 In this way, by downregulating these main pro-inflammatory cytokinesand affecting the inflammatory milieu, DHA liposomes can directlyimpair GBM growth and progression. The gene discussed is AKT1; the disease is glioblastoma.