To test the hypothesis that NOX2 deficiency in T cells contributed to autoimmunity in SLE, we crossed the Cybbfl/fl with CD4-Cre (54) MRL.Faslpr strains to generate a cohort of experimental Cybbfl/fl CD4-Cre–positive mice and Cre-negative Cybbfl/fl controls. This evidence concerns the gene CD4 and systemic lupus erythematosus.