To determine whether NOX2 in the hematopoietic or stromal compartment is the primary driver of the exacerbated manifestations of autoimmunity that we and others observed in global NOX2-deficient mice (19–23, 26, 27), we first generated bone marrow (BM) chimeras in MRL.Faslpr SLE-prone mice using Cybb-KO or control Cybb-sufficient donor BM. The gene discussed is CYBB; the disease is systemic lupus erythematosus.