BACE1 and Alzheimer disease: Notably, oligodendrocyte-specific knockout of BACE1 led to a greater reduction in plaque area in cortical Layers 5/6 as compared to Layers 2/3 specifically within the retrosplenial cortex, which is known to be a selectively vulnerable site of early plaque deposition and functional impairment in AD [37] (S12A and S12E Fig), albeit not within the motor cortex (S12B and S12F Fig).