GPT and Cognitive impairment: Additionally, we conduct an analysis of the threshold effect to identify specific threshold values for liver enzymes worthy of consideration, specifically when ALP > 60 U/L, the AST/ALT ratio fell within the range of 0.77 to 1.76, and GGT ranged from 25 to 94 U/L, a higher levels of liver enzymes were found to be significantly associated with an increased risk of cognitive impairment.