Results indicated a significant correlation between cognitive function and various factors, including age, race, educational status, income level, BMI (except for CREAD), physical activity, alcohol consumption, presence of chronic diseases (including diabetes, hypertension, and stroke), ALB, ALP, ALT, AST/ALT ratio, GGT (in globe cognitive performance and AFT), TC and serum creatinine (SCr) levels (P < 0.05). The gene discussed is ALB; the disease is stroke disorder.