,10,37 Additionally, the few formerly reported studies concurrently assessing for p16 and MTAP IHC in circumscribed and adult-type diffuse gliomas28,38,39 have shown variable results but, overall, a high sensitivity (from 87% to >90% and up to 100% for p16 and MTAP, respectively) and specificity (up to 89% and 97% for p16 and MTAP, respectively) of these markers to detect HD of CDKN2A/B. This evidence concerns the gene CDKN2A and Huntington disease.