,24,25 Within CNS tumors, CDKN2A HD is a hallmark of PXA,7 and more recently it has been recognized as an adverse prognostic factor in IDH-mutant diffuse gliomas, pediatric low-grade glial/glioneuronal tumors, supratentorial ependymomas, and meningiomas.26–31. This evidence concerns the gene CDKN2A and pleomorphic xanthoastrocytoma.