To identify the profibrotic myeloid cell subsets involved in driving the activation of FAP+ fibroblasts, we performed unsupervised reclustering of the myeloid compartment (LYZ, CTSG, CD68, CSF1R), and we identified a total of 14 clusters in the CD ileum and in the healthy CRC control ileum (Figure 4, A and B, and Supplemental Figure 4A). This evidence concerns the gene CD68 and colorectal carcinoma.