PD-L2 is highly expressed in head and neck squamous cell carcinoma (Yearley et al. 2017), renal cell carcinoma (Shin et al. 2016), pancreatic ductal adenocarcinoma (Zhang et al. 2019), and cervical cancer (2017). The gene discussed is PDCD1LG2; the disease is hereditary clear cell renal cell carcinoma.