Furthermore, according to the UK Biobank, the C allele has been shown to be associated with lower coffee intake (p = 1.3e-27), increased risk for hypertension (p = 1.2e-35), lower vitamin D levels (p = 0.003), lower serum albumin levels (p = 0.0000021), lower mean corpuscular volume (p = 0.0037) and lower physical activity as measured by the frequency of stair climbing in the last 4-weeks (p = 0.0025) [34]. This evidence concerns the gene ALB and hypertensive disorder.