Interestingly, LDH, total serum IgE, and tryptase levels were higher than normal in nine (32.1%), 15 (53.6%), and 16 (57.1%) patients, respectively, while autoimmune tests were positive for ANA, anti-dsDNA or ANCA in nine (32.1%) patients in total, however without an underlying diagnosis of an autoimmune disease. This evidence concerns the gene IGHE and autoimmune disease.