STAT3 and Sepsis: Particularly, it was shown to suppress STAT3 activation in a variety of inflammation and injury models, including neuroinflammation, intestinal mucosal injury induced by ischemia-reperfusion damage, as well as heart, kidney, lung, and liver injury induced by sepsis and ischemia-reperfusion (Si et al. 2013, 2014; Chen et al. 2017, 2023; Zhang et al. 2019a; Pan et al. 2020; Jia et al. 2022; Li et al. 2022; Liu et al. 2022).