Actually, supplementation with Trp metabolites has been shown to protect mice from ethanol‐induced steatohepatitis[43] and inflammatory bowel diseases (IBD) by reducing gut permeability via activation of AhR.[16] In this study, typical OVX mice models with and without intestinal AhR knockout were employed to explore the underlying mechanisms by which IAA and IPA treatments improve bone loss via regulating gut‐bone signaling axis (Figure 7G). This evidence concerns the gene AHR and inflammatory bowel disease.