Thus, PP2A may also be involved in tumor immunity by regulating macrophage localization and function in tumors.[33] Additionally, PP2A‐SET interactions have been found to induce granzyme B expression and modulate human natural killer (NK) cell cytotoxicity.[34] Although PP2A can participate in regulatory roles in various cellular subpopulations, its subunits, including PP2Ac, have received little attention in OA, particularly in osteoclast studies. Here, GZMB is linked to neoplasm.