HAS2 and breast cancer: For example, it was previously shown that a bone‐metastasizing breast cancer cell line cultured in 2D produced more HA via enhanced HAS2 expression compared to its parental cell line.[53] We further show increased HAS2 expression in MDA‐MB‐468 MVNs relative to MDA‐MB‐468 cultured in 2D, pointing towards a better recapitulation of the 3D breast cancer microenvironment.