CD44 and neoplasm: Conversely, HYAL2 expression was increased (Figure S7c, Supporting Information), similar to CD44 expression (Figure 2f), as previously observed in the tumor microenvironment.[41] Vascular glycocalyx degradation was further confirmed by a severe decrease in HA concentration in the periphery of SKBR3 and MDA‐MB‐468 tumoroids (between 0.5 mm and 1.5 mm from the tumoroids) compared to control MVNs (Figure 2g).