MDA‐MB‐468 tumoroid MVNs also presented higher concentrations of IL12, TNFα, and CCL4 compared to control MVNs (Figure 3a), consistent with the more pro‐inflammatory milieu expected in later stages of breast cancer desmoplasia.[47] These increased cytokine concentrations were local to the tumoroids, as analysis of the supernatant collected from the MVN devices revealed much smaller changes relative to control MVNs (Figure S8b, Supporting Information). Here, TNF is linked to breast carcinoma.