Thus, MEN1 is thought to play a key role in tumorigenesis and cancer development.[6] A transgenic mouse model showed that homozygous deletion of MEN1 results in death at E11.5‐13.5.[45] Thus, conditional knockout mice, such as pancreas‐specific MEN1‐KO mice, are often used to assess the function of MEN1 after genetic alteration. Here, MEN1 is linked to cancer.