KMT2A and neoplasm: For example, in contrast to that in solid tumors, MEN1 was shown to play a tumor suppressor role by assembling a histone methyltransferase complex with MLL1 that promotes the transcription of target genes (i.e., HOX) and cell proliferation in liquid tumors.[48] Based on data presented in previous studies, our results suggested that MEN1 is shuttled between the cytoplasm and the nucleus in PanNETs.