A recent study reported that hypoxanthine phosphoribosyl transferase 1 (HPRT1) is identified to metabolize TMZ to activate AMPK (Adenosine 5‘‐monophosphate (AMP)‐activated protein kinase) and RRM1(the catalytic subunit of ribonucleotide reductase) and increase the production of dNTPs that supplement the damaged DNA induced by TMZ in glioblastoma. Here, RRM1 is linked to glioblastoma.