MGMT and pancreatic neoplasm: Compared with the control group, the combination of β‐Catenin suppression and TMZ treatment led to significant synergistic inhibition of orthotopic pancreatic tumors and Ki67 expression in lesions, while the forced‐expression of MGMT strongly counteracted the orthotopic pancreatic tumor growth inhibition and the reduced expression of Ki67 induced by the synergistic effect of β‐Catenin depletion and TMZ treatment (Figure 8M,P).