Three weeks after injection, compared with the negative control group, the overexpression of MGMT notably promoted orthotopic pancreas‐seeded tumor growth (n = 5, p < 0.05), according to the gross anatomy of the mouse pancreas (Figure 1F) and the fluorescence intensity of the lesion (Figure 1H), which was associated with poorer survival (Figure 1G). Here, MGMT is linked to neoplasm.