By contrast, despite patients with low levels of MGMT expression having a favorable outcome compared with those with high levels of MGMT in our study, TMZ resistance is still observed in glioblastoma (GBM) cells with MGMT negative.[54] The possible mechanism for the chemoresistance of gliomas is that β‐catenin, the phosphor‐Akt and the phosphor‐PRAS40 are increased, thus inducing Epithelial‐to‐mesenchymal transition (EMT) in TMZ‐resistant GBM cells, indicating that mechanisms other than mediated by MGMT expression lead to drug resistance from the cell‐type specific context. The gene discussed is AKT1S1; the disease is glioma.