We speculate that the anti‐fluorosis mechanism of action of ASP may be through promotion of renal fluoride excretion, reducing the levels of fluoride and inflammatory factors in the body, increasing the antioxidant level in the body, mediating the SIRT1/BDNF/TrkB signaling pathway to regulate the brain damage caused by fluorosis, and reducing the apoptosis of neurons. The gene discussed is NTRK2; the disease is dental fluorosis.