Among the 15 variants with > 99% posterior assignment to both AInonT and skin cancer shared groups are well known missense variants in PTPN22, TYK2, IFIH1, FUT2 and CCDC88B, as well as the low-frequency ZAP70 and IRF3 variants noted above, an intronic FLT3 variant that prematurely truncates FLT3, and several other established immune-mediated disease loci at CTLA4, BACH2 and IL2RA. The gene discussed is IRF3; the disease is skin cancer.