Recently, it has been reported that ZIP4 promoted the development of pancreatic cancer through the zinc finger E-box binding homeobox 1 (ZEB1)/Integrin α3β1/equilibrative nucleoside transporter (ENT1) 1,2 and zona occludens 1 (ZO-1)/claudin-1/ZEB1 pathways.3 Here, TJP1 is linked to familial pancreatic carcinoma.