Some herbal ingredients, such as salidroside (NF-κB/NLRP3 axis) [60], lonicerin (mitochondrial autophagy) [61], andrographolide (triggering mitochondrial dysfunction) [62], and celastrol (K63 deubiquitination) [63], have been found to play a role in lung injury, ulcerative colitis, renal tubulointersticial injury, and liver damage through targeting the NLRP3 inflammasome. This evidence concerns the gene NFKB1 and ulcerative colitis.