Endothelial dysfunction has been observed in a mouse model of CKD, as evidenced by a marked decrease in glycocalyx thickness and density, upregulation of glycocalyx components, impaired acetylcholine‐induced endothelium‐dependent relaxation, and elevated expression of ICAM1 and VCAM1 in EC.152, 153, 154. Here, ICAM1 is linked to chronic kidney disease.