Additionally, exosomes from angiotensin‐converting enzyme 2 (ACE2)‐enriched endothelial progenitor cells (EPC) have been found to suppress cellular senescence, oxidative stress, apoptosis, and endothelial dysfunction through the activation of the miR‐17‐5p/PTEN/PI3K/Akt signaling pathway, ultimately ameliorating cerebrovascular injury in elderly ischemic stroke mice.57 This evidence concerns the gene ACE2 and endothelial dysfunction.