In a study by Panigrahi et al., 74 (43.5%) out of 170 acute undifferentiated febrile illness (AUFI) patients were diagnosed scrub typhus by IgM ELISA; 44 (or 59% of the total) were male, with a male-to-female ratio of 1.46:1. Here, CD40LG is linked to scrub typhus.