IL12B and complication: The MR estimates demonstrated that the genetically elevated predicted levels of IL12B (IVW: OR 1.691, 95% CI 1.179–2.427, P =4.34×10-3) and LIF interleukin 6 family cytokine (LIF) (IVW: OR 1.349, 95% CI 1.010–1.801, P =4.23×10-2) were associated with an increased risk of T1D with renal complications.