PPIB and steatosis: Potent and selective liver X receptor (LXR)β agonist; commits human mesenchymal cells to adipose lineage. LXR is involved in the tissue distribution of fat (visceral vs. sub-cutaneous vs. skeletal muscle) and activation reverses cholesterol transport. LXR activation induces steatosis and may affect pancreatic beta cells. Crosstalk with PPARγ.Limited amount of supporting literature retrieved, therefore lower priority for test method development, although interesting and important mechanistically.