In our study, we observed alterations in several pathways that are known to be implicated in epilepsy and seizure pathogenesis, such as IER genes, IGF1, ERK/MAPK, EIF2 signaling, oxidative stress, inflammation, changes in extracellular matrix, increased excitatory neurotransmission through glutamatergic signaling, and decreased inhibitory neurotransmission along with suppression of calcium signaling. The gene discussed is EIF2S2; the disease is epilepsy.