MAPK3 and epilepsy: The ERK/MAPK pathway, implicated in SE, seizure, and epilepsy (Hansen et al., 2014; Gangarossa et al., 2015; Ahmed et al., 2021) showed early dysregulation during the acute phase (Figures 8C,D), which genes such as dual-specificity phosphatase 6 (Dusp6), specific for ERK1/2 (Queipo et al., 2017), being upregulated at the 1-h time point, but then down regulated at 36 and 120 h.