PTH and hypercalcemia disease: On the other hand, the benefits of vitamin D repletion in PTPH are multiple, as this preoperative intervention may limit disease progression and reduce gland size and postoperative PTH elevation [19]. Nevertheless, although there is some evidence that vitamin D repletion does not aggravate hypercalcemia or hypercalciuria, PHPT patients should be closely monitored because large studies are still lacking [20-22].