Different major dysregulated biosignatures including but not limited to Interferon Alpha 1 (IFNA1), Interferon Alpha Inducible Protein 6 (IFI6), Toll-Like Receptor 4 (TLR4) and interleukin-6 (IL6) are linked to host responses to COVID-19 (Bernardes et al., 2020; Ovsyannikova et al., 2020; Schulte-Schrepping et al., 2020; Aschenbrenner et al., 2021). Here, TLR4 is linked to COVID-19.