The most prevalent are the anti-N-methyl-D-aspartate receptor (NMDAR), anti-myelin oligodendrocytic glycoprotein (MOG), anti-leucine-rich glioma inactivated 1 (LGI1), anti-contactin-associated protein 2 (CASPR2), anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR), anti-gamma-aminobutyric acid A receptor (GABAAR), anti-metabotropic glutamate receptor (mGluR) and anti-glycine receptor (GlyR) autoantibodies, and some of them are often related with neoplasms (paraneoplastic autoantibodies) while others are not (2–4). The gene discussed is CNTNAP2; the disease is neoplasm.