Furthermore, approximately 20% of mucinous colorectal carcinomas exhibit mutations in V-raf murine sarcoma viral oncogene homolog B1 (BRAF) (42).The amplification of Human Epidermal Growth Factor Receptor-2 (HER2), also known as ERBB2, is found in approximately 20–30% of invasive MOC cases and 6% of mucinous borderline tumors (MBTs), contrasting with its rarity in colorectal and non-mucinous carcinomas (42). This evidence concerns the gene ERBB2 and mucinous adenocarcinoma.