Validation in the Ki-67-prostate set showed that patients with high Ki-67 had significantly shorter TTR compared to patients with low Ki-67 tumours for both manual (HR = 1.92, 95 % CI 1.21–3.05) and DL scores (HR = 1.81, 95 % CI 1.13–2.90), (Fig. 4a (E and F), Table 2). The gene discussed is MKI67; the disease is neoplasm.