In the PTEN-prostate set used for development, patients with PTEN-loss had significantly shorter TTR compared to those with PTEN-present tumours for both manual scores (HR = 2.41, 95 % CI 1.57–3.70) and DL scores (HR = 1.96, 95 % CI 1.27–3.02) (Fig. 5 (A and B), Table 2). Here, PTEN is linked to neoplasm.