Additionally, TLR4 signaling contributes to proper AT2 renewal and lung repair.92 In the case of COVID-19, the ectodomain of the SARS-CoV-2 spike protein has been consistently reported to stimulate TLR4.93,94 Without adequate internalization of TLR4 by ATP11A, downstream immune signaling may be overactivated, leading to hypersecretion of proinflammatory cytokines. The gene discussed is TLR4; the disease is COVID-19.