A relative lack of attention has been devoted to the regulation of feeding behaviour by BDNF at the hypothalamus compared with its neuroprotective function; the improvements in cognition and mood associated with BDNF would not be redundant in many peri- and postmenopausal women, presenting another potential dual benefit of irisin for postmenopausal women beyond MetS management (52). This evidence concerns the gene FNDC5 and metabolic syndrome.