INS and obesity due to melanocortin 4 receptor deficiency: Obese individuals with relatively high gluteofemoral subcutaneous adipose tissue (SAT) mass are often described as having “metabolically healthy” obesity in which insulin sensitivity is largely retained, as opposed to the “metabolically unhealthy” phenotype of greater abdominal SAT and, more significantly, intra-abdominal visceral adipose tissue (VAT) deposition (23).