FNDC5 and inherited lipid metabolism disorder: Additionally, the benefits of irisin for postmenopausal dyslipidaemia driven by oestradiol depletion require thorough investigation, possibly using ovariectomised obese mouse models, as unlike many of the parallel actions previously considered in this review, irisin appears to attenuate dyslipidaemia via distinct mechanisms that do not recapitulate the molecular actions of oestradiol.