APOA1 and bacterial infectious disease: In addition, ApoA-I was also found to possess in vitro antimicrobial properties against Gram-positive and Gram-negative bacteria in studies with tilapia, and ApoA-I inhibited inflammation and apoptosis and increased the likelihood of survival to bacterial infection (74), and its antimicrobial effect is not affected by temperature, even when the a-helix of ApoA-I is damaged by high temperature, ApoA-I still has the activity of killing bacteria directly (75).